Vitals Curcumin SLCP Curcumin is one of the most well-known and widely used herbal preparations. It is the main active ingredient in turmeric, an aromatic spice from the root of the Curcuma longa plant. Turmeric originates in Indian cuisine, where it is a key ingredient in famous curry dishes, often called koenjit or turmeric.
Curcumin-SLCP™: A Technological Breakthrough
The biggest challenge in developing curcumin preparations with optimal efficacy is overcoming the problems with its absorption and bioavailability. Curcumin in its "raw" form is rapidly converted in the intestines and liver after oral administration into inactive metabolites, such as curcumin glucuronide, which are quickly excreted from the body. Verdure Sciences, the manufacturer of Vitals' Curcumine-SLCP™, has succeeded in solving these problems after years of research and collaboration with the University of California (UCLA). Using their patented technology, they have increased curcumin's absorption by 65x and its bioavailability by a staggering 285x (compared to standard curcumin preparations containing 95% curcumin). This breakthrough was achieved after testing many different formulations for their bioavailability in humans. The most optimal results were achieved with a formulation inspired by Indian cuisine, where turmeric is mixed with oily components in the preparation of curry pastes. Their curcumin product, branded Longvida®, uses Solid Lipid Curcumin Particles, where the curcumin is encapsulated in a fatty particle composed of three long-chain fats also found in food: phosphatidylcholine, stearic acid, and ascorbyl palmitate.
How is Curcumin-SLCP™ absorbed into the body?
Normally, curcumin is absorbed in the same way as most other nutrients (e.g., sugars and amino acids). In the intestinal epithelium, an initial enzymatic conversion of biologically active curcumin into curcumin glucuronide, an inactive metabolite, already occurs. The curcumin then travels via the portal vein to the liver, where it is further inactivated and then excreted relatively quickly. However, Curcumin-SLCP™ utilizes an alternative route of absorption into the body. Due to its unique lipid coating, it is recognized by the body and treated in the same way as other long-chain dietary fats. These are incorporated into chylomicrons (transport particles) in the intestinal cells and transported via the lymphatic system into the bloodstream. These chylomicrons initially bypass the liver but are transported via the blood to various tissues and organs, where they release their contents under the influence of a fat-splitting enzyme (lipoprotein lipase). The curcumin in the chylomicron remains in its biologically active form, also called "free" curcumin. In this form, it is released from the chylomicron and absorbed into tissues and organs where it can exert its effects. Biologically active (free) curcumin itself is a lipid-like substance and can thus even cross the blood-brain barrier, unlike its inactive metabolites, and support the functioning of the central nervous system.
Absorption versus bioavailability
The bioavailability of a particular substance is often discussed. This refers to the maximum blood level (Cmax) reached at a specific time after oral ingestion of a nutrient. Bioavailability is part of bioavailability, but it certainly doesn't tell the whole story. A nutrient can be absorbed very well and quickly reach a very high blood level, but then be broken down very quickly and eliminated from the body without having sufficient time to take effect. It's important to also consider the development of the blood level over time, not just the moment at which the maximum blood level is reached. What matters is how long the nutrient has been present in the blood in its biologically active form and how long it has had the opportunity to exert its effects. This reflects bioavailability, which is defined as the portion of a nutrient that has been absorbed into the body and is available for use in specific bodily processes.
Due to its high bioavailability, Curcumine-SLCP™ requires only a low effective dose. And because it remains active in the body for a long time, a single daily dose is sufficient. This has many advantages in terms of user-friendliness. Not everyone can tolerate high doses of curcumin, and it's also easier to only have to think about taking a supplement once a day.
Compound
| Composition per daily dose of 1 capsule:
|
|
| Curcumin-SLCP™ (Longvida®) |
400 mg |
| Of which curcumin |
80 mg |
Ingredients Curcumin (extract from Curcuma longa), stabilizers (stearic acid, phosphatidylcholine [from SOY lecithin]), hydroxypropyl methylcellulose (vegetable capsule), rice starch (Oryza sativa), maltodextrin, anti-caking agents (silicon dioxide, magnesium salts of fatty acids), antioxidant (ascorbyl palmitate).
Usage Take 1 capsule daily with water during a meal. Follow the recommended dosage.
Suitable for vegetarians and vegans.
NB:
Consult your doctor or pharmacist if you are taking anticoagulants and other medications at the same time. Do not use if you are pregnant, breastfeeding, or have children under 18, have biliary tract disorders, or have existing liver problems. Turmeric can rarely cause liver problems. Consult your doctor if you experience jaundice or other unusual symptoms.
Storage instructions Store dry, closed and at room temperature.
Manufacturer / Distributor Vitals nutritional supplements BV,
Reply number 894,
1500 VB Zaandam
This product is a dietary supplement.
Do not exceed the recommended dosage.
A varied, balanced diet and a healthy lifestyle are important. A dietary supplement is not a substitute for a varied diet.
Keep out of reach of young children.
Store in a dry, closed container at room temperature, unless otherwise advised on the label.
Consult an expert before using supplements in case of pregnancy, lactation, taking medication or illness.
